Alzheimer's Disease

Alzheimers disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy.Alzheimers Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimers disease.

Alzheimers is a Multifactorial Disease;
The Genetic and Biochemical Basis of Alzheimers Disease;
Alzheimers Disease Pathology: A Tau Perspective;
Structural Insights Into the Amyloidogenic Ab and Tau Species in Alzheimers disease Pathophysiology: Defining Functional Motifs for Therapeutic Interventions;
Structural Insights on Aggregation Species of Ab and Tau, and Their Implications in Alzheimers Disease;
Aggregation Species of Amyloid-b and Tau Oligomers in Alzheimers Disease: Role in Therapeutics and Diagnostics;
Role of Metal Ions in Alzheimers Disease: Mechanistic Aspects Contributing to Neurotoxicity;
Microglial Blockade of the Amyloid Cascade: A New Therapeutic Frontier;
Post-translational Modifications and Alzheimers Disease;
Autophagy: Role in Alzheimers Disease Pathophysiology and Therapeutic Avenues;
Transmission of Pathogenic Proteins and the Role of Microbial Infection in Alzheimers Disease Pathology;
The Role of Gut Microbiome in Alzheimers Disease and Therapeutic Strategies;
Molecular Probes for the Diagnosis of Alzheimers Disease with Implications for Multiplexed and Multimodal Strategies;
Circulating Biomarkers for the Diagnosis of Alzheimers Disease;
Lactoferrin: A Potential Theranostic Candidate for Alzheimers Disease;
Multifunctional Inhibitors of Multifaceted Ab Toxicity of Alzheimers Disease;
Tau-targeting Therapeutic Strategies for Alzheimers Disease;
Computational Development of Alzheimers Therapeutics and Diagnostics;
Targeted Protein Degradation as a Therapeutic Avenue for Alzheimers Disease;
Cell-based Therapy for Alzheimers Disease;
Experimental Models to Study Alzheimers Disease;
Ethnic and Racial Differences in The Pathophysiology of Alzheimers Disease